食管癌术后不同肠内营养配方的治疗效益

目的比较食管癌患者术后安素、能全素和百普力3种早期肠内营养配方的治疗效益。方法前瞻性入组2011年9—11月间福建省肿瘤医院胸外科收治的45例食管癌患者。按随机数字表法分为安素组、能全素组和百普力组,每组均15例。各组患者均于术后第2天给予管饲肠内营养素．连续8d。分别于术前1d和术后9d空腹采血以检测患者的白蛋白和前白蛋白．并记录术后胃肠道功能恢复时间、相关并发症发生率及营养支持费用。结果3组患者术后营养指标（血清白蛋白和前白蛋白）及肠内营养相关并发症发生率的差异均无统计学意义（P〉0．05）。安素组和能全素组患者术后肠道功能恢复时间分别为（52．4±15．73）h和（50-8±12．4）h。均明显快于百普力组（60．3±16．8）h,P〈0．05]。安素组患者营养支持费用为（443．3±45．8）元,明显低于能全素组（639．5±52．6）元]和百普力组（990．5±95．5）元]（P〈0．01）。结论安素、能全素和百普力3种肠内营养制剂用于食管癌患者术后早期肠内营养支持．其营养效果和并发症发生率相同：安素治疗费用最低。

Study of different enteral nutrition formulation treatment after esophagectomy

Objective To compare the efficiency of different early enteral nutrition （EN） with Ensure, Nntrison, and Peptison in postoperafCve patients with esophageal carcinoma. Methods A total of 45 postoperative patients with esophageal carcinoma were randomly divided into three groups using random digit table： Ensure group （n=lS）, Nutrition group （n=lS）, and Peptison group （n=lS）. Enteral nutrition was given using nasogastric tube from the 2nd postoperative day for 8 days. Albumin and prealbumin were detected on the day before surgery and postoperative day 9 after fasting. The time to gastrointestinal tract function recovery, complications, and the cost of enteral nutrition were compared among the three groups. Results There were no significant differences in postoperative nutrition indices （albumin and prealbumin） and EN-related complications among the three groups （all P〉0.05）. The time to gastrointestinal tract function recovery in Ensure group （52.4＋15.7） hi and Nutrison group （50.8±12.4） hi was less than that in Peptison group （60.3±16.8） hi （P〈0.05）. The expense of Ensure group （443.3±45.8） RMB] was obviously less than that of Nutrison group （639.5±52.6） RMB] and Peptison group （990.5±95.5） RMB ] （both P 〈0.01 ）. Conclusions Ensure, Nutrison and Peptison can be used for postoperative early enteral nutrition in patients with esophageal carcinoma, and the efficacy and complication are comparable. The cost of Ensure is the lowest.