Cyclization-activated prodrugs. Basic esters of 5-bromo-2'-deoxyuridine |
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| Authors: | W S Saari J E Schwering P A Lyle S J Smith E L Engelhardt |
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| Affiliation: | Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486. |
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| Abstract: | Some 3'- and 5'-[[(alkylamino)ethyl]glycyl] esters of 5-bromo-2'-deoxyuridine were prepared and evaluated in vitro as progenitors of the parent alcohol. The esters proved to be relatively stable at low pH but released 5-bromo-2'-deoxyuridine cleanly at rates which were pH and structure dependent. These basic esters are examples of cyclization-activated prodrugs in which generation of active drug is not linked to enzymatic cleavage but rather results from an intramolecular cyclization-elimination reaction. |
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