依巴斯汀联合雷尼替丁在慢性荨麻疹中的综合疗效

目的：探讨依巴斯汀联合雷尼替丁在慢性荨麻疹中的综合疗效。方法：选取2008年6月～2010年11月于本院进行治疗的86例慢性荨麻疹患者为研究对象,将其随机分为对照组（西替利嗪联合雷尼替丁组）43例和观察组（依巴斯汀联合雷尼替丁组）43例,后将两组患者的治疗总有效率、不良反应发生率及治疗前后的血清总IgE、HA、ECP、5-HT、LT水平进行统计及比较。结果：观察组的治疗总有效率高于对照组,不良反应发生率低于对照组,血清总IgE、HA、ECP、LT水平低于对照组,血清5-HT高于对照组,P〈0.05或P〈0.01,差异有统计学意义或显著统计学意义。结论：依巴斯汀联合雷尼替丁在慢性荨麻疹中的综合疗效较佳,可影响血清总IgE、HA、ECP、5-HT、LT水平,可以作为治疗慢性荨麻疹的方案。

The comprehensive therapeutic effect of ebastine combined with ranitidine in chronic urticaria

Objective：To study the comprehensive therapeutic effect of ebastine combined with ranitidine in chronic urticaria.Methods：86 patients with chronic urticaria in our hospital from June 2008 to November 2010 were selected as research object,and they were randomly divided into control group（cetirizine combined with ranitidine group） 43 cases and observation group（ebastine combined with ranitidine group） 43 cases,then the total effective rate,incidence of adverse reactions and serum total IgE,HA,ECP,5-HT,LT of two groups before and after the treatment were analyzed and compared.Results：The total effective rate of observation group was higher than that of control group,incidence of adverse reactions was lower than that of control group,serum total IgE,HA,ECP,serum LT were lower,5-HT was higher,P〈0.05 or P〈0.01,there were significant or very significant differences.Conclusion：The comprehensive therapeutic effect of ebastine combined with ranitidine in chronic urticaria.It can influence the serum total IgE,HA,ECP,5-HT,LT and it can be the therapeutic scheme of chronic urticaria.