自体角膜缘上皮干细胞移植与单纯翼状胬肉切除术疗效比较

目的：观察翼状胬肉单纯切除术与翼状胬肉切除加自体角膜缘干细胞移植术的临床疗效。方法：将2006年3月～2010年6月78例（93眼）翼状胬肉患者随机分为翼状胬肉单纯切除术组（对照组）及翼状胬肉切除加自体角膜缘干细胞移植术组（治疗组）,比较其疗效。结果：采用翼状胬肉单纯切除术后患者复发率为13.3%,上皮修复时间为（5.83±0.84）d;而采用自体角膜缘干细胞移植后复发率仅为2.08%,上皮修复时间为（3.02±0.79）d,且两者相比,差异有统计学意义（P〈0.05）。结论：翼状胬肉切除加自体角膜缘干细胞移植术与翼状胬肉单纯切除术相比,可以有效地降低复发率,而且缩短角膜上皮修复时间,是治疗翼状胬肉较为理想有效的方法。

Comparison of efficacy between limbal epithelial stem cell autografting transplantation and simple pterygium excision

Objective：To analyze 78 cases（93 eyes） of pterygium by operative treatment in our hospital and to explore the curative effect of pterygium excision with limbal stem cell autograft transplantation for treatment of pterygium.Methods：78 cases（93 eyes） were divided into two groups randomly.36 patients（45 eyes） with primary pterygium were treated by simple excision technique patients;42 patients（48 eyes） with primary pterygium were treated by limbal stem cells autografting technique.Results：Recurrent rate was 13.3% and corneal epithelium were recovered with（5.83±0.84） days in simple pterygium excision group,but in the therapeutic group the recurrent rate was 2.08% and corneal epithelium were recovered with（3.02±0.79） days.There was statistically significant difference in the recurrence rate between the patients who underwent simple excision and those who underwent limbal conjunctival autografting（P〈0.05）.Conclusion：Limbal stem cells autografting is an effective surgical technique for the treatment of primary pterygium.It has a low recurrence rate when compared with the simple excision technique.