| 系统性红斑狼疮患者CD40—CD40L的检测及临床意义 |
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| 引用本文： | 黄爱军,陈军浩,欧阳建,夏永泉,张葵,李浩.系统性红斑狼疮患者CD40—CD40L的检测及临床意义[J].江西医学检验,2003,21(5):339-340. |
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| 作者姓名： | 黄爱军 陈军浩 欧阳建 夏永泉 张葵 李浩 |
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| 作者单位： | 江苏省南京大学医学院附属鼓楼医院医学检验中心
210008(黄爱军，陈军浩，欧阳建，夏永泉，张葵)，江苏省南京大学医学院附属鼓楼医院医学检验中心 210008(李浩) |
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| 摘 要： | 目的探讨CD40-CD40L在系统性红斑狼疮(SLE)患者淋巴细胞上的表达及意义。方法采用流式细胞术检测SLE患者淋巴细胞CD40及CD40L的表达,并与对照组比较。结果SLE患者淋巴细胞及CD4+T淋巴细胞CD40L的表达显著高于对照组(P<0.05),而CD40在淋巴细胞及CD3-淋巴细胞上的表达,两组无显著性差异(P>0.05)。结论CD40-CD40L共刺激分子途径在SLE发病机制中起重要作用,以CD40L表达上调为重要特点。
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| 关 键 词： | 系统性红斑狼疮 CD40 CD40L 检测 流式细胞术 淋巴细胞 外周血 |
| 文章编号： | 1008-0023(2003)05-0339-02 |
Expression and its clinical significance of CD40-CD40L in peripheral blood of patients with systemic lupus erythmatosus |
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| HUANG Aijun CHEN J unhao,OUYANG Jian,et al..Expression and its clinical significance of CD40-CD40L in peripheral blood of patients with systemic lupus erythmatosus[J].Jiangxi Journal of Medical Laboratory Sciences,2003,21(5):339-340. |
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| Authors: | HUANG Aijun CHEN J unhao OUYANG Jian |
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| Institution: | HUANG Aijun CHEN J unhao,OUYANG Jian,et al.Department of Clinical Laboratory,Affiliated Drum Tower Hospital,Medi cal College of Nanjing University,Nan jing210008,China |
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| Abstract: | Objective To insestigate the expression and its clinical significance o f CD40and CD40L on lymphocytes of patients with systemic lupus erythmatosus (SLE).Methods The expression of CD40and CD40L on lymphocyte,or on CD4 + T lympho-cytes,or on CD3-lymphocytes from patients with SLE and from controls were measured by flow c ytometry.Results The expression of CD40L on lymphocytes,and on CD4 + T lymphocyte s from patients with SLE both increased markedly.There was not significant difference between the SLE group and control group.Conclusions T he CD40-CD40L co-stimulalive molecules plays an important role in the pat hogenesis of SLE.CD40L up-regulating on lymphocyte s was the more important phenomenon. |
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| Keywords: | flow cytometry CD40 CD40L systemic lupus erythm atosus |
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