| G-CSF和GM-CSF对髓系白血病细胞增殖的影响 |
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| 引用本文： | 杨力建,李扬秋,陈少华,李荣福,张玉平,罗更新.G-CSF和GM-CSF对髓系白血病细胞增殖的影响[J].广东医学,2001,22(2):122-123. |
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| 作者姓名： | 杨力建 李扬秋 陈少华 李荣福 张玉平 罗更新 |
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| 作者单位： | 1. 暨南大学医学院血液病研究所
2. 暨南大学医学院第一附属医院血液科 |
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| 摘 要： | 目的 了解粒细胞集落刺激因子（Ｇ－ＣＳＦ）和粒细胞－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）对髓系白血病细胞增殖的影响。方法 采用甲基纤维素半固体培养法培养白血病细胞集落（ＣＦＵ－Ｌ），观察Ｇ－ＣＳＦ和ＧＭ－ＣＳＦ对１１例ＡＭＬ和ＣＭＬ患者外周血ＣＦＵ－Ｌ形成的影响。结果 ＣＭ－ＣＳＦ对ＣＦＵ－Ｌ的促进作用明显高于Ｇ－ＣＳＦ（Ｐ＝０．０１２），而Ｇ－ＣＳＦ对ＣＦＵ－Ｌ形成影响与对照组没有显著性差别（Ｐ＝０．４９５）。结论 Ｇ－ＣＳＦ对髓系白血病细胞体外增殖无明显影响，作为髓系白血病大剂量化疗的支持治疗可能更为安全。
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| 关 键 词： | G－CSF 髓系白血病 GM－CSF 细胞增殖 |
| 修稿时间： | 2000年9月4日 |
The effect of G-CSF and GM-CSF on the proliferation of myeloid leukemic cells |
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| Yang Lijian,Li Yangqiu,Chen Shaohua,et al..The effect of G-CSF and GM-CSF on the proliferation of myeloid leukemic cells[J].Guangdong Medical Journal,2001,22(2):122-123. |
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| Authors: | Yang Lijian Li Yangqiu Chen Shaohua |
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| Institution: | Yang Lijian,Li Yangqiu,Chen Shaohua,et al.Department of Hematology,Medical College,Jinan University,Guangzhou 510632 |
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| Abstract: | Objective To analyse the effect of G-CSF (Granocyte) and GM-CSF on proliferation of myeloid leukemic cells. Methods\ Methylcellulose semi-solid culture assay was used to evaluate the effect of G-CSF and GM-CSF on peripheral blood colony forming units-leukemia (CFU-L) in 11 patients with AML or CML. Results The stimulatory effect of GM-CSF in CFU-L was significant higher than G-CSF( P =0 012), and in compare with the control group the effect of proliferation of G-CSF in CFU-L was not significant ( P =0 495). Conclusion\ The effect of G-CSF on the colony-forming capacity of myeloid leukemic cells is not significant in vitro. It may be safer to use G-CSF for supporting high-dose chemotherapy in myeloid leukemia. |
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| Keywords: | G-CSF Myeloid leukemia Colony forming-units-leukemia |
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