| SDF-1／CXCR4在老年卵巢癌组织中的表达及意义 |
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| 引用本文： | 李雅丽,辛维政,王轶英. SDF-1／CXCR4在老年卵巢癌组织中的表达及意义[J]. 老年医学与保健, 2011, 17(6): 349-350,356. DOI: 10.3969/j.issn.1008-8296.2011-06-10 |
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| 作者姓名： | 李雅丽 辛维政 王轶英 |
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| 作者单位： | 1. 河南省人民医院妇产科,郑州市,450003
2. 河南省人民医院麻醉科,郑州市,450003 |
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| 基金项目： | 基金项目：河南省医学科技攻关计划（2011020138） |
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| 摘 要： | 目的探讨趋化因子SDF-1及其受体CXCR4在老年人上皮性卵巢癌组织中的表达及意义。方法应用westernblotting方法定量检测43例老年患者上皮性卵巢癌组织中SDF-1和CXCR4的蛋白表达情况。结果老年人上皮性卵巢癌组织中SDF-1／CXCR4蛋白表达较卵巢良性肿瘤对照组明显增加，其相对表达量分别为（2．38±0．20）和（3．32±0．26），差异具有统计学意义（P〈0．05）。结论SDF-1／CXCR4生物学轴可能在老年人卵巢癌的发生与转移过程中起着重要作用。
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| 关 键 词： | 老年人 基质细胞衍生因子-1（SDF-1） CXC族趋化因子受体4（CXCR4） 卵巢癌 |
Expressions of chemokine SDF-1 and its receptor CXCR4 in epithelial ovarian tumor of elderly patients and its clinical significance |
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| LI Ya-li,XIN Wei-zheng,WANG Yi-ying. Expressions of chemokine SDF-1 and its receptor CXCR4 in epithelial ovarian tumor of elderly patients and its clinical significance[J]. Geriatrics & Health Care, 2011, 17(6): 349-350,356. DOI: 10.3969/j.issn.1008-8296.2011-06-10 |
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| Authors: | LI Ya-li XIN Wei-zheng WANG Yi-ying |
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| Affiliation: | . Department of Obstetrics .and Gynecology, Henan Province People＇s Hospital, Zhengzhou 450003, China |
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| Abstract: | Objective To investigate the expressions and clinical significance of chemokine SDF-1 and its receptor CXCR4 in elderly patients with epithelial ovarian tumor. Methods 43 cases with epithelial ovarian cancer were studied ran- domly. The expressions of SDF-1 and CXCR4 proteins were detected by Western blotting. Results There were weak ex- pression of SDF-1 and modest expression of CXCR4 in benign ovarian tumor of elderly patients. The expressions of SDF-1 protein and CXCR4 protein were significantly increased in epithelial ovarian cancer, compared with benign ovarian tumor （2.38±0.20 vs 3.32±0.26） （P〈0.05）. Conclusion SDF-1/CXCR4 may play a role in the malignant transformation of primary ovarian cancer and involve in the initiation, progression and metastasis of ovarian cancer of elderly patients. |
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| Keywords: | Elderly SDF-1 CXCR4 Epithelial ovariantumor |
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