河豚毒素对局麻药的局麻作用和毒性的影响

利多卡因和普鲁卡因与河琢毒素(TTX)EC_5合用于小鼠坐骨神经麻醉,其EC_(50)均比它们单用为低(P<0.05,P< 0.01),且麻醉持续时间明显延长;在家兔硬膜外麻醉中,合用与单用的EC_(50)未见显著差异,但均延长麻醉持续时间;在家兔角膜麻醉中,利多卡因与TTX合用,其EC_(50)比单用利多卡因低(P<0.05),而普鲁卡因与TTX合用的EC_(50)与单用普鲁卡因无显著性差异。两药与TTX(EC_5)合用的LD_(50)(小鼠)均与单用无显著差异,但可提高它们的治疗指数。

THE LOCAL ANESHETIC ACTIVITY AND TOXICITY OF TETRODOTOXIN IN COMBINATION WITH USUAL LOCAL ANESTHETICS

In sciatic nerve anesthesia in mouse. EC_(50) produced by combinations oflidocaine or procaine with TTX(EC_5)Were markedly lower than that obtaiuedwith them alone, the durations of lccal anesthetics action were also much longer. There was no significant difference observed between the EC_(50) of thelocal anesthetics alone and that resulted from combinations with TTX(EC_5)in peridural anesthesia in rabbit. but the durations of action induced by combined administration were markedly longer.ln cornea anesthesia in rabbit,the EC_(50) obtained with combination of lidocaine with TTX(EC_5) was muchsmaller than that produced by it alone, but the EC_(50) of combination of procaine with TTX(EC_5) was not different from that induced by it alone. he LD_(50) of combinations of them with TTX(EC_5) and that of themselves were not significantly different.