| 利拉萘酯致突变作用的研究 |
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| 引用本文： | 张耿月,周晓军,宋连生. 利拉萘酯致突变作用的研究[J]. 癌变．畸变．突变, 2007, 19(2): 155-156. DOI: 10.3969/j.issn.1004-616X.2007.02.022 |
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| 作者姓名： | 张耿月 周晓军 宋连生 |
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| 作者单位： | 吉林省肿瘤防治研究所,长春,130012 |
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| 摘 要： | 背景与目的:研究利拉萘酯是否具有潜在的遗传危害.材料与方法:采用Ames试验、中国仓鼠肺细胞染色体畸变试验、小鼠骨髓微核试验对利拉萘酯的突变性进行研究.结果:利拉萘酯各剂量对中国仓鼠肺细胞的染色体无畸变作用;对小鼠骨髓嗜多染红细胞的微核率无增加作用;对4种试验菌株均未引起回变菌落数增加.结论:利拉萘酯在本试验的剂量范围内无致突变效应.
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| 关 键 词： | 利拉萘酯 致突变性 微核 Ames试验 |
| 文章编号： | 1004-616X（2007）02-0155-02 |
| 收稿时间： | 2006-03-31 |
| 修稿时间： | 2006-11-25 |
Mutagenicity Study on Liranaftate |
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| ZHANG Geng-yue,ZHOU Xiao-jun,SONG Lian-sheng. Mutagenicity Study on Liranaftate[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2007, 19(2): 155-156. DOI: 10.3969/j.issn.1004-616X.2007.02.022 |
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| Authors: | ZHANG Geng-yue ZHOU Xiao-jun SONG Lian-sheng |
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| Affiliation: | Jilin Provincal Tumor Research Institute, Changchun 130012, China |
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| Abstract: | BACKGROUND & AIM: To explore the mutagenicity of Liranaftate. MATERIALS AND METHODS: The mutagenicity of liranaftate was tested by the micronucleus assay, chromosomal aberration test of CHL and the Ames assay. RESULTS: It was found that all of the tests that mentioned above were negative. CONCLUSION: Liranaftate had no mutagenicity in this test. |
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| Keywords: | liranaftate mutagenicity micronucleus Ames test |
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