立体定向适形放射治疗丘脑和脑干区肿瘤30例疗效分析

目的分析评价立体定向适形放疗(SCRT)对丘脑和脑干区肿瘤的疗效.方法 1997年10月至2002年4月我院采用SCRT技术(WDXK-808治疗计划系统)治疗丘脑和脑干区肿瘤30例.其中男性19例,女性11例.年龄13～68岁,中位37岁.肿瘤大小(计划靶体积)3.5～73.0 cm3.8例为常规照射加SCRT、7例为手术后SCRT、15例为单独SCRT.结果患者临床症状缓解率100%;KPS评分明显提高(P<0.01),肿瘤局部控制有效率83.3%.随访6～54个月(中位24个月),1～4年生存率分别为88.3%、74.5%、65.2%和65.2%.并发症发生率13.3%.结论 SCRT是丘脑和脑干区肿瘤的有效治疗手段之一,配合手术有可能取得更好疗效.

Stereotactic conformal radiotherapy for 30 cases of thalamic and brainstem tumors

Objective To evaluate the therapeutic effects of stereotactic conformal radiotherapy (SCRT) on 30 cases of thalamic and brainstem tumors. Methods During the period from October 1997 to April 2002, 30 patients, 19 male and 11 female, with an age range from 13 to 68 years (an average of 37 years) suffering from thalamic and brainstem tumors, were treated in our institute. The size of the tumors ranged from 3.5 cm 3 to 73.0 cm 3 with an average of 16.5 cm 3. Eight cases were treated with SCRT after regular radiotherapy, 7 cases were treated with SCRT after surgical resection of the tumor and 15 cases were treated with SCRT only. Results The clinical symptoms of all the patients disappeared thoroughly. Their KPS was significantly improved (P<0.01). Most tumors decreased in their size with an effective rate of 83.3%. The patients were followed up for 6 to 54 months with an average of 24 months. The survival rate of one, two, three and four years was 88.3%, 74.5%, 65.2% and 65.2% respectively. Complications occurred in 13.3% of the patients. Conclusion SCRT is a safe and effective measure to treat thalamic and brainstem tumors. Better therapeutic effects can be obtained when SCRT is administered after surgical intervention of the tumor.