孕产期妇女甲型H1N1流感防治进展

与季节性流感和历次流感大流行相似,甲型H1N1流感大流行过程中,孕妇感染甲型H1N1流感的风险增高,孕妇甲型H1N1流感的患病率、病死率增高,易继发严重并发症.因此,基于疗效-风险评估,无接种禁忌证的孕妇,妊娠各期均应接种甲型H1N1流感疫苗.出现流感样症状或与甲型H1N1流感患者密切接触的孕妇,都应接受神经氨酸酶抑制剂(更推荐奥司他韦)治疗或预防,无需等待实验室检查结果证实甲型H1N1流感感染.感染甲型H1N1流感的哺乳产妇,神经氨酸酶抑制剂对接受授乳的婴儿是安全的.甲型H1N1流感流行期间,孕妇应采取非药物预防措施,降低感染甲型H1N1流感的风险.

Progress in prevention and treatment of the 2009 H1N1 pandemic of pregnancy women

Pregnancy women are at increased risk of being infected with novel influenza virus A (H1N1), have higher morbidity and mortality during the current H1N1 pandemic, and are prone to develop more severe complications, which is similar to seasonal influenza and influenza pandemics in the history.Therefore, pregnancy women without contradictions for vaccination are recommended to take inactivated H1N1 influenza vaccine in all trimesters of pregnancy based on benefit- risk analysis.For pregnancy women with influenza - like illness or closely contacting with H1N1 influenza patients,neuroaminidase inhibitors (osehamivir) are recommended as pharmacotherapy and chemoprophylaxis at all stages of pregnancy.The initiation of neuroaminidase inhibitor pharmacotherapy in this patient group should not wait confirmation of H1N1 infection by laboratory results.Neuroaminidase inhibitors are compatible with breast-feeding.During the pandemic, pregnancy women are encouraged to take non -pharmacological preventive approaches to reduce risks of influenza infection.