Detection of thyroid tumour using a monoclonal 123I anti-human thyroglobulin antibody |
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Authors: | P. S. Shepherd C. R. Lazarus R. D. Mistry M. N. Maisey |
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Affiliation: | (1) Department of Chemical Pathology, Guy's Hospital Medical School, SE1 9RT London, United Kingdom;(2) Department of Nuclear Medicine, Guy's Hospital, London, United Kingdom |
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Abstract: | A monoclonal antibody to human thyroglobulin was radiolabelled with 123I NaI and shown to be a stable and biologically active reagent in vivo. When injected intravenously into 12 patients with cancer of the thyroid on thyroxine-replacement therapy, 6 of the 12 patients had localization of the labelled antibody in tumour sites. These results were compared to 131I scans done on the same patients 1 month after stopping thyroxine. The biological half-life of the antibody in the blood was influenced by the levels of circulating thyroglobulin. |
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Keywords: | Monoclonal anti-human thyroglobulin antibody Imaging Thyroid metastases |
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