| 大鼠肢体缺血再灌注早期血栓前状态的研究 |
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| 引用本文： | 杨敏,马平,徐文会,张宏江. 大鼠肢体缺血再灌注早期血栓前状态的研究[J]. 实用骨科杂志, 2008, 14(9): 530-533 |
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| 作者姓名： | 杨敏 马平 徐文会 张宏江 |
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| 作者单位： | 山西医科大学第二附属医院麻醉科,山西,太原,030001 |
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| 摘 要： | 目的探讨大鼠急性下肢缺血再灌注早期血栓的形成情况。方法将大鼠随机分为假手术组、下肢缺血再灌注组两组。夹闭大鼠股动脉并用张力带绑扎下肢，建立急性下肢缺血再灌注大鼠模型。观察急性下肢缺血再灌注大鼠血小板膜糖蛋白GPⅡb／Ⅲa和血管内皮细胞血栓调节蛋白（thrombomoclulin，TM）的表达。结果缺血再灌注组大鼠血小板膜糖蛋白GPⅡb／Ⅲa表达高于假手术组（P〈0．05）；缺血再灌注组大鼠血管内皮TM表达低于假手术组（P〈0．05）。结论急性下肢缺血再灌注可能导致大鼠血栓前状态的形成。
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| 关 键 词： | 肢体缺血再灌注 血栓前状态 血小板膜糖蛋白 血栓调节蛋白 |
Prethrombotic State in Rats after lschemia-reperfusion of Limb and it''s Intervention Study |
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| Affiliation: | YANG Min, MA Ping, XU Wen-hui ,et al (Department of Anesthesia,the 2nd Hospital of Shanxi Medical University,Taiyuan 030001 ,China) |
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| Abstract: | Objective To investigate the emerge condition of thromb in rats after ischemia-reperfusion of limb. Methods The rats were randomly divided into 2 groups：sham operation group （N group）;the hind limb ischemia reperfusion group （IR group）. An animal model of acute hind limb ischemia-reperfusion was developed by clamping femoral artery and banding hind limb of rats. Changes in the expression of GP Ⅱ b/Ⅲ a of platelet membrane and TM of vascular endothelial cell in rats after ischemia-reperfusion of limb were observed. Results The expression of GP Ⅱ b/Ⅲ a of platelet membrane in the IR group was significantly higher than that of the N group （P〈0.05）. The expression of TM of vascular endothelial cell in the IR group was significantly lower than that of the N group （P〈0.05）. Conclusion Acute hind limb ischemia-reperfusion mav induce the formation of prethrombotic state in rats. |
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| Keywords: | limb ischemia-reperfusion prethrombotic state platelet membrane lycoprotein thrombomodulin |
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