老年男性患者血清抵抗素与血脂水平的相关性研究

目的观察老年男性患者血清抵抗素与血脂水平的关系。方法选择老年(≥80岁)男性患者220例,根据血脂水平分为血脂异常组(80例)和血脂正常组(140例),使用酶联免疫法测定空腹血清抵抗素浓度,并分析两者关联。结果血脂异常组患者空腹血清抵抗素浓度较血脂正常组高[(7.16±0.77)ng/ml比(6.21±0.63)ng/ml,P<0.05],血清抵抗素浓度与总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平呈负相关(γ=-0.231,-0.254,-0.243,均为P<0.01),与三酰甘油水平呈正相关(γ=0.127,P<0.01),在控制了年龄、病史和相关用药后,高密度脂蛋白胆固醇与抵抗素水平独立相关(P=0.017)。结论老年男性血脂异常患者空腹血清抵抗素浓度升高,可能与脂代谢紊乱有关。

Correlation between serum resistin and blood lipids levels in old male patients

Objective To investigate the correlation between serum resistin and blood lipids in old male patients.Methods A total of 220 male patients over 80 years old were selected and divided into hyperlipidemia group(n=80) and normal lipid group(n=140) according to their blood lipids level.The serum resistin concentration was measured by ELISA.Results Serum resistin level was significantly higher in hyperlipidemia group than in normal lipid group[(7.16±0.77) ng/ml vs.(6.21±0.63) ng/ml,P<0.05].Serum resistin level was negatively correlated with TC,LDL-C,HDL-C(γ=-0.231,-0.254,-0.243,all P<0.01),and positively correlated with TG(γ=0.127,P<0.01).Resistin was independently correlated with HDL-C after controlling the age and medical history(P=0.017).Conclusions Serum resistin level is higher in old male patients with hyperlipidemia and may be related to the disorder of blood lipid.