奥卡西平与左乙拉西坦治疗新诊断部分性发作癫痫患儿的疗效分析

目的观察奥卡西平与左乙拉西坦对新诊断部分性发作癫痫患儿的疗效和安全性。方法将80例新诊断部分性发作癫痫患儿随机分为2组,奥卡西平组和左乙拉西坦组各40例。奥卡西平组给予奥卡西平,开始剂量10 mg·kg-1·d-1,分2次服用,以后每周增加1次剂量,每次加量5 mg·kg-1·d-1,至最小有效量,最大剂量60 mg·kg-1·d-1,左乙拉西坦组给予左乙拉西坦,开始剂量5 mg·kg-1·d-1,分2次服用,以后每周增加1次剂量,每次加量5 mg·kg-1·d-1,至最小有效量,最大剂量60 mg·kg-1·d-1,2组均观察6～12个月。观察2组的疗效及不良反应。结果奥卡西平组实际完成治疗39例,因皮疹退出1例,癫痫发作完全控制26例,出现不良反应8例,其中头晕2例,嗜睡1例,认知功能减退5例;左乙拉西坦组实际完成治疗38例,因经济原因退出2例,癫痫发作完全控制28例,出现脾气暴躁不良反应2例。结论奥卡西平与左乙拉西坦治疗儿童部分性发作均有效,但左乙拉西坦更安全,对认知功能无明显影响,缺点是价格偏高。

Effect of levetiracetam and oxcarbazepine on children with epilepsy newly diagnosed partial seizure

Objective To observe the effect of oxcarbazepine and levetiracetam on children epilepsy with newly diagnosed partial seizure.Methods Eighty cases of children with epilepsy newly diagnosed partial seizure were randomly divided into OXC group(treated with oxcarbazepine,40 cases) and LEV group(treated with levetiracetam,40 cases).OXC group began at the dose of 10 mg·kg-1·d-1,then 5 mg·kg-1·d-1 was added per week until to the minimum effective dose,but the maximum dose was 60 mg·kg-1·d-1.LEV group began at the dose of 5 mg·kg-1·d-1,then 5mg.kg-1.d-1 was added per week until to the minimum effective dose,but the maximum dose was 60 mg·kg-1·d-1.Then the curative and side effect of the two groups within 6-12 months were observed.Results Thirty-nine cases completed the treatment in OXC group,including the full control of 26 cases,but 1 case exited because of erythra,and 8 cases showed the adverse reaction,including dizziness(2 cases),drowsiness(1 case) and cognitive impairment(5 cases).Thirty-eight cases completed the treatment in LEV group,including the full control of 28 cases,but 2 cases exited because of economic condition,and 2 cases showed the adverse reaction of bad-temper.Conclusion LEV has the similar effect to and is safer than OXC on children with newly diagnosed partial seizure,which has no obvious influence on cognitive function,but the price is high.