| 胃癌组织中DLC-1Ki-67蛋白的表达及临床意义 |
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| 引用本文： | 汤华,赵铁.胃癌组织中DLC-1Ki-67蛋白的表达及临床意义[J].安徽医学,2012,33(11):1473-1475. |
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| 作者姓名： | 汤华 赵铁 |
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| 作者单位： | 铜陵市人民医院外科,244000;铜陵市人民医院病理科,244000 |
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| 摘 要： | 目的检测胃癌组织中DLC-1、Ki-67蛋白的表达,分析其与胃癌临床病理特征关系及预后的关系。方法免疫组织化学EnVision两步法,检测66例胃癌和20例癌旁组织中DLC-1和Ki-67的表达,分析其表达与胃癌临床病理特征及预后的关系。结果 DLC-1和Ki-67蛋白表达与肿瘤分化程度、淋巴结转移及TNM分期相关;与性别、肿瘤部位等无关;胃癌中DLC-1与Ki-67的表达呈负相关(rs=-0.673,P<0.05),且DLC-1低表达组及Ki-67高表达组术后5年生存率显著降低。结论 DLC-1和Ki-67有望成为胃癌生物学行为的参考指标。
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| 关 键 词： | 胃癌 DLC-1 Ki-67 免疫组织化学 预后 |
Expression and cinical significance of DLC-1 and Ki-67 proteins in gastric carcinoma |
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| Tang Hua,Zhao Tie.Expression and cinical significance of DLC-1 and Ki-67 proteins in gastric carcinoma[J].Anhui Medical Journal,2012,33(11):1473-1475. |
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| Authors: | Tang Hua Zhao Tie |
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| Institution: | Department of Surgery,the People’s Hospital of Tongling,Tongling 244000,China |
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| Abstract: | Objective To investigate the expression of DLC-1 and Ki-67 in gastric cancer and adjacent normal gastric tissues and analyze the expression and its relation with clinicopathologic characteristics of gastric cancer and the prognosis.Methods The expression of DLC-1 and Ki-67 in 66 cases gastric cancer and 20 adjacent normal tissues was detected by immunohistochemiscal EnVision method and the relation of its expression with clinicopathologic characteristics of gastric cancer and the prognosis was analyzed.Results DLC-1 and Ki-67 were related to the differentiation,lymph node metastasis and clinical stages;no relation with gender and tumor location was found.DLC-1 protein expression was negatively correlated with Ki-67 protein expression(rs=-0.67,P<0.05).The 5-year survival rate of DLC-1 low expression and Ki-67 high expression was significantly low.Conclusion Combining detection of DLC-1 and Ki-67 may be useful parameter for evaluating the biological behaviors of gastric cancer. |
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| Keywords: | Gastric cancer DLC-1 Ki-67 Immunohistochemical Prognosis |
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