血清Cys C联合尿mAlb监测肝豆状核变性肾小球损害的价值

目的研究HLD患者Cys C和mAlb水平及其对诊断HLD肾小球损伤的意义。方法使用粒子增强免疫透射比浊法,对211例HLD患者和47名正常对照者,分别检测血清Cys C和尿液mAlb。按尿常规检查是否正常,将211例HLD患者中的150例分为尿常规检查正常组(61例)和尿常规检查异常组(89例);在各组之间进行血清Cys C和尿液mAlb水平比较。结果HLD患者血清Cys C和尿液mAlb水平均显著高于正常对照组;尿常规检查异常组尿液mAlb水平均显著高于尿常规检查正常组。结论 HLD患者肾小球滤过功能存在损害;尿液mAlb反应HLD患者肾小球损伤的敏感性高于血清Cys C。

Diagnostic value of monitoring serum Cys C and urine mAlb level of glomerular damage in patients with hepato-lenticular degeneration

Objective To detect serum Cystatin C(SCys C) and urine albumin(mAlb) in patients with hepato-lenticular degeneration(HLD),and to evaluate the significance in the diagnosis of HLD patients with glomerular injury.Methods The levels of SCys C and mAlb of 211 HLD patients and 47 normal controls were detected with particle enhanced turbidimetric immunoassay.All 150 HLD patients were divided into normal urine routine examination group and abnormalities urine routine examination group according to their urine routine examination results.The levels of SCys C and mAlb of each group were compared.Results The levels of SCys C and mAlb in HLD patients were significantly higher than those in the normal controls(P<0.01 orP<0.05).The levels of mAlb of the abnormalities urine routine examination group were significantly higher than those of the normal urine routine examination group,and the levels of SCys C showed no statistically significant differences for them.Conclusion Glomerular filtration rate was damaged for HLD patients.The level of mAlb was more sensitive than that of SCys C for HLD patients with glomerular injury.