| 海藻真菌菌株 Aspergillus sp. AF044 中的两个新天然产物 |
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| 引用本文： | 董卓,郑忠辉,鲁春华,沈月毛.海藻真菌菌株 Aspergillus sp. AF044 中的两个新天然产物[J].中国天然药物,2010(5):370-372. |
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| 作者姓名： | 董卓 郑忠辉 鲁春华 沈月毛 |
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| 作者单位： | 厦门大学生命科学学院药物微生物工程实验室,厦门361005 |
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| 基金项目： | 教育部重大项目（No.306010）资助 |
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| 摘 要： | 目的：研究海藻真菌 Aspergillus sp. AF044 的化学成分。方法：通过色谱层析柱对提取物进行分离纯化, 并通过波谱解析（一维、二维的核磁共振谱和质谱）确定化合物的结构。结果：分离纯化得到3个化合物, 分别鉴定为6-hydroxy-5-methoxy- 3-methyl-3, 6-dihydro-2H-pyran-4-carboxylic acid （1）, 8, 9-dihydroxy-8, 9-deoxyaspyrone（2） and penicillic acid（3）。结论：化合物 1和 2 是首次发现的新化合物。化合物 3 在多种真菌菌株中分离得到。
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| 关 键 词： | Aspergillus sp. AF044 光谱数据 Aspyrone |
Two New Compounds Isolated from A Seaweed-associated Fungus, Aspergillus sp. AF044 |
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| DONG Zhuo,ZHENG Zhong-Hui,LU Chun-Hua,SHEN Yue-Mao.Two New Compounds Isolated from A Seaweed-associated Fungus, Aspergillus sp. AF044[J].Chinese JOurnal of Natural Medicines,2010(5):370-372. |
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| Authors: | DONG Zhuo ZHENG Zhong-Hui LU Chun-Hua SHEN Yue-Mao |
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| Institution: | (Xiamen Engineering Research Center of Marine Microbial Drug Discovery; Fujian Laboratory of Pharmaceutical Engineering; School of Life Sciences, Xiamen University, Xiamen 361005, China) |
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| Abstract: | AIM： To study the chemical constituents of the seaweed fungus Aspergillus sp. AF044. METHODS： The fermentation extract was isolated and purified by column chromatography （MPLC, Sephadex LH-20, normal Si gel）. RESULTS： Three compounds （1 - 3） were isolated and determined as 6-hydroxy-5-methoxy-3-methyl-3, 6-dihydro-2H-pyran-4-carboxylic acid （1）, 8, 9-dihydroxy-8, 9-deoxyaspyrone （2） and penicillic acid （3） based on their spectral data （1↑H, 13↑C, HMQC, HMBC, 1↑H-1↑H COSY and NOE）. CONCLUSION： 1 and 2 are new compounds; Penicillic acid was isolated from many fungi. |
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| Keywords: | AspergUlus sp AF044 Spectral data Aspyrone |
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