| 告达庭在大鼠体内的药代动力学研究（英文） |
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| 引用本文： | 彭蕴茹,王大为,丁永芳,罗宇慧,李友宾,刘晓东. 告达庭在大鼠体内的药代动力学研究（英文）[J]. 中国天然药物, 2010, 0(6): 471-473 |
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| 作者姓名： | 彭蕴茹 王大为 丁永芳 罗宇慧 李友宾 刘晓东 |
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| 作者单位： | [1]江苏省中医药研究院药理毒理研究室,南京210028 [2]中国药科大学药物代谢与动力学研究中心,南京210009 |
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| 基金项目： | 国家自然科学基金（No.30973978）和江苏省自然科学基金项目（Nos.BK2008488、BK2009457） |
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| 摘 要： | 目的：研究化合物告达庭口服给药后在大鼠体内的药代动力学过程。方法：大鼠单次灌胃给予告达庭后,于不同时间点采血以LC/ESI-MS/MS法检测血浆中药物浓度,并计算药代动力学参数。结果：大鼠分别单次口服10,20,40mg·kg-1剂量的告达庭后其半衰期分别为（1.59±1.08）,（0.99±0.27）,（1.92±1.55）h;AUC0-t分别为（220.6±114.8）,（539.1±160.6）,（1631.9±915.9）μg·h·L-1;cmax分别为（153.5±79.1）,（232.8±119.3）,（687.9±245.7）μg·L-1;tmax为（0.36±0.35）,（1.33±0.61）,（0.96±0.68）h。其AUC与给药剂量间呈现出非线性相关性。结论：在本实验所用剂量范围内告达庭在大鼠体内的动力学过程基本符合非线性动力学特征。
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| 关 键 词： | 告达庭 药代动力学 高效液相-串联质谱 |
Oral Pharmacokinetics of Caudatin in Rats |
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| PENG Yun-Ru,WANG Da-Wei,DING Yong-Fang,LUO Yu-Hui,LI You-Bin,LIU Xiao-Dong. Oral Pharmacokinetics of Caudatin in Rats[J]. Chinese JOurnal of Natural Medicines, 2010, 0(6): 471-473 |
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| Authors: | PENG Yun-Ru WANG Da-Wei DING Yong-Fang LUO Yu-Hui LI You-Bin LIU Xiao-Dong |
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| Affiliation: | 1 Department of Pharmacology and Toxicology, Jiangsu Provincial Institute of Traditional Chinese Medicine, Nanjing 210028, China; 2 Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | AIM： To study the pharmacokinetics after oral administration of caudatin in rats. METHODS： Blood samples of rats were collected at predetermined intervals for the assay of caudatin after oral administration and the plasma concentration of caudatin was analyzed by LC/ESI-MS/MS method. The pharmacokinetic parameters were also calculated. RESULTS： The half-lives of caudatin were examined to be （1.59 ± 1.08）, （0.99 ± 0.27）, （1.92 ± 1.55） h after oral administration with caudatin at doses of 10, 20, 40 mg·kg-1. The AUC0-t were （220.6 ± 114.8）, （539.1 ± 160.6）, （1631.9 ± 915.9） μg·h·L-1, respectively. The cmax were （153.5 ± 79.1）, （232.8 ± 119.3）, （687.9 ± 245.7） μg·L-1, respectively. The tmax were （0.36 ± 0.35）, （1.33 ± 0.61）, （0.96 ± 0.68） h, respectively. The relationship between AUC0-t and dose was non-linear. CONCLUSION： The result suggested that the pharmacokinetics of caudatin in rats conform to non-linear kinetics. |
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| Keywords: | Caudatin Pharmacokinetics Liquid chromatography-tandem mass spectrometry |
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