The insulin-like growth factor 1 receptor in cancer: old focus, new future |
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| Authors: | Hartog Hermien Wesseling Jelle Boezen H Marike van der Graaf Winette T A |
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| Affiliation: | Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
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| Abstract: | The importance of insulin-like growth factor 1 receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently, development of drugs targeting the IGF-1R as anticancer treatment is emerging. Several IGF-1R targeting strategies are being investigated in phases I and II clinical trials. Interactions of IGF-1R with insulin receptor, however, might complicate efficiency and tolerability of such drugs. This review describes mechanisms, recent developments and potential limitations of IGF-1R antibodies and tyrosine kinase inhibitors. |
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