Menopause rather than estrogen modifies plasma homocysteine levels. |
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Authors: | D Marchesoni L Driul L Plaino M T Villani L Becagli B Mozzanega |
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Affiliation: | Department of Surgical Sciences, University of Udine, Udine, Italy. diego.marchesoni@dsc.uniud.it |
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Abstract: | OBJECTIVES: To investigate the effects of transdermal estrogen replacement therapy (ERT) on plasma homocysteine levels in postmenopausal women who underwent total hysterectomy with bilateral oophorectomy. METHODS: In two-phase open longitudinal prospective study we compared 28 premenopausal women and 35 healthy postmenopausal patients to evaluate the effect of transdermal estrogen treatment (TTS 50 twice-weekly) on plasma homocysteine levels after 6 and 12 months of therapy. RESULTS: The study showed statistically relevant differences (P<0.05) in baseline plasma homocysteine concentration between the patients in premenopausal and in postmenopausal status. No difference in the plasma homocysteine levels was observed after 6 and 12 months of ERT on postmenopausal patients. CONCLUSIONS: Surgically postmenopausal women have higher plasma homocysteine concentrations than premenopausal women, but transdermal estrogen treatment for 12 months in postmenopausal women does not modify homocysteine levels. |
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Keywords: | Homocysteine Cardiovascular risk Menopause Estrogen replacement therapy |
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