Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations |
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Authors: | Pravitt Gourh Sandeep K. Agarwal Ezequiel Martin Dipal Divecha Blanca Rueda Haley Bunting Shervin Assassi Gene Paz Sanjay Shete Terry McNearney Hilda Draeger John D. Reveille T.R.D.J. Radstake Carmen P. Simeon Luis Rodriguez Esther Vicente Miguel A. Gonzalez-Gay Maureen D. Mayes Filemon K. Tan Javier Martin Frank C. Arnett |
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Affiliation: | 1. Dental Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA;2. Secretory Mechanisms and Dysfunction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA;3. Sjögren Syndrome Clinic, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA |
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Abstract: | ObjectiveGenetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class II, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE). These data suggest that there are common autoimmune disease susceptibility genes. The current report sought to determine if polymorphisms in the C8orf13-BLK region (chromosome 8p23.1-B lymphoid tyrosine kinase), which is associated with SLE, are associated also with SSc.MethodsTwo variants in the C8orf13-BLK region (rs13277113 & rs2736340) were tested for association with 1050 SSc cases and 694 controls of North Americans of European descent and replicated in a second series 589 SSc cases and 722 controls from Spain.ResultsThe “T” allele at rs2736340 variant was associated with SSc in both the U.S. and Spanish case–control series (P = 6.8 × 10?5, OR 1.27, 95% CI 1.1–1.4). The “A” allele at rs13277113 variant was associated with SSc in the U.S. series only (P = 3.6 × 10?4, OR 1.32, 95% CI 1.1–1.6) and was significant in the combined analyses of the two series (P = 2.0 × 10?3; OR 1.20, 95% CI 1.1–1.3). Both variants demonstrated an association with the anti-centromere antibody (P = 2.2 × 10?6 and P = 5.5 × 10?4, respectively) and limited SSc (P = 3.3 × 10?5 and P = 2.9 × 10?3, respectively) in the combined analysis. Peripheral blood gene expression profiles suggest that B-cell receptor and NFκB signaling are dysregulated based on the risk haplotype of these variants.ConclusionWe identify and replicate the association of the C8orf13-BLK region as a novel susceptibility factor for SSc, placing it in the category of common autoimmune disease susceptibility genes. |
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