| 中药及其单体对骨髓间充质干细胞诱导分化的研究进展 |
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| 引用本文： | 杨斌,王楠,谭睿,王琴,顾健. 中药及其单体对骨髓间充质干细胞诱导分化的研究进展[J]. 中草药, 2022, 53(24): 7915-7924 |
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| 作者姓名： | 杨斌 王楠 谭睿 王琴 顾健 |
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| 作者单位： | 西南民族大学药学院, 四川 成都 610041;西南交通大学生命科学与工程学院, 四川 成都 611756 |
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| 基金项目： | 国家自然科学基金面上项目(82174083);四川省重点研发项目(20ZDYF3291);四川省科技厅项目(2019YFS0157);教育部重点实验室开放课题(KF2020009) |
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| 摘 要： | 骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）是骨髓内的非造血干细胞，具有自我更新能力和多向分化潜能，在一定条件下可以分化为成骨细胞、心肌细胞、神经细胞和肝细胞，是目前组织工程、基因工程较为理想的种子细胞。通过归纳总结现有文献，主要从BMSCs的生物学特性、中药及其单体诱导BMSCs多向分化进行探讨，以期为后续的研究提供一定的理论依据。
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| 关 键 词： | 中药 单体 骨髓间充质干细胞 成骨细胞 心肌细胞 神经细胞 肝细胞 |
| 收稿时间： | 2022-06-07 |
Research progress on induction and differentiation of bone marrow mesenchymal stem cells by traditional Chinese medicine and its monomers |
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| YANG Bin,WANG Nan,TAN Rui,WANG Qin,GU Jian. Research progress on induction and differentiation of bone marrow mesenchymal stem cells by traditional Chinese medicine and its monomers[J]. Chinese Traditional and Herbal Drugs, 2022, 53(24): 7915-7924 |
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| Authors: | YANG Bin WANG Nan TAN Rui WANG Qin GU Jian |
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| Affiliation: | College of Pharmacy, Southwest Minzu University, Chengdu 610041, China;College of Life Science and Engineering, Southwest Jiaotong University, Chengdu 611756, China |
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| Abstract: | Bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic stem cells in bone marrow with self-renewal ability and multidirectional differentiation potential, which can differentiate into osteoblast, myocardial cells, nerve cells, and hepatic cells under certain conditions. It is an ideal seed cell for tissue engineering and genetic engineering. By summarizing the existing literature, biological characteristics of BMSCs, traditional Chinese medicine and its monomers to induce BMSCs multidirectional differentiation were mainly discussed in this review, in order to provide a certain theoretical basis for the follow-up research. |
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| Keywords: | traditional Chinese medicine monomer bone marrow mesenchymal stem cells osteoblast myocardial cells nerve cells hepatic cells |
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