老年2型糖尿病病人血清尿酸/肌酐比值与胰岛素抵抗及胰岛B细胞功能的相关性

目的探讨老年2型糖尿病(T2DM)病人血清尿酸/肌酐比值(SUA/SCr)与胰岛素抵抗及胰岛B细胞功能的相关性。方法选择老年T2DM病人784例(男512例,女272例),均行75 g口服葡萄糖耐量试验(OGTT),并测定SUA、SCr、TG、TC、LDL-C、HDL-C、HbA1c、葡萄糖、胰岛素等指标水平,并计算胰岛素抵抗指数(HOMA-IR)和B细胞功能指标。结果SUA/SCr水平越高的病人,年龄越小,HbA1c及SCr水平越低,BMI、TG、UA及eGFR水平越高,差异均有统计学意义(均P<0.01)。SUA/SCr与HOMA-IR(r=0.112,P=0.002)、胰岛分泌功能(HOMA-β)(r=0.189,P<0.001)、InsAUC30(r=0.164,P<0.001)、IG30(r=0.140,P<0.001)、InsAUC120(r=0.193,P<0.001)、IG120(r=0.169,P<0.001)均呈正相关,进一步校正年龄、性别、糖尿病病程、BMI及TG后,上述相关性仍存在(均P<0.01)。结论老年T2DM病人血清SUA/SCr水平与胰岛素抵抗及胰岛B细胞功能独立正相关。

Association of serum uric acid to creatinine ratio with insulin resistance and B-cell function in elderly patients with type 2 diabetic

Objective To explore the association between serum uric acid to creatinine ratio(SUA/SCr)and insulin resistance or B-cell function in the elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 784 elderly T2DM patients(512 males and 272 females)were enrolled.All patients underwent 75 g oral glucose tolerance test(OGTT).The levels of SUA,SCr,triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),hemoglobin A1c(HbA1c),glucose,and insulin were measured.Insulin resistance and B-cell function indexes were calculated.Results The patients with higher level of SUA/SCr were younger,and had lower levels of HbA1c and SCr,while had higher levels of BMI,TG,SUA and eGFR(all P<0.01).SUA/SCr was positively correlated with HOMA-IR(r=0.112,P=0.002),HOMA-β(r=0.189,P<0.001),InsAUC30(r=0.164,P<0.001),IG30(r=0.140,P<0.001),InsAUC120(r=0.193,P<0.001)and IG120(r=0.169,P<0.001).After further adjustment for age,gender,diabetic duration,BMI and TG,the above correlations remained(all P<0.01).Conclusions SUA/SCr in the elderly patients with T2DM are positively associated with insulin resistance and B-cell function.