海岛中老年男性部分雄激素缺乏综合征的流行病学调查

目的了解海岛地区中老年男性部分雄激素缺乏综合征(PADAM)的患病情况。方法采用多级抽样的方法,选取舟山市定海区612例45岁以上中老年男性进行PADAM自我症状评定量和外周静脉血雄激素水平测定,根据相应判断依据进行PADAM的诊断并用二项分布原理进行人群患病率的估计,采用方差分析或卡方检验等方法比较不同年龄组间的差异。结果PADAM自我症状评定结果显示:中老年男性PADAM患病率为39.87%(95%CI:35.99%～43.75%),不同年龄组差别有统计学意义(P<0.05),且各类症状得分值均随年龄的增高而上升;激素水平测定结果显示:舟山海岛中老年男性PADAM患病率为30.72%(95%CI:27.06%～34.38%),除黄体生成素水平和性激素结合蛋白随年龄增加而升高外,总睾酮、游离睾酮、游离睾酮指数等均随着年龄的增加而下降。结论舟山海岛中老年人PADAM的患病率较高,各年龄组间存在差异,今后应进一步加强对PADAM的相关研究,为提高中老年男性的身心健康和改善生活质量提供科学的依据。

Epidemiological Investigation of Partial Androgen Deficiency in Aging Male (PADAM) in the Island Area

Objective The present study was designed to understand the situation of PADAM in the island area.Methods A method of multi-stage sampling was adopted,and in this method,612 cases of ageing males aged 45 years or more were selected to conduct self-evaluation of PADAM symptom and determination of androgen level in peripheral venous blood,and a PADAM diagnosis was performed according to relevant standards,and at the same time,the morbidity rate among people was evaluated based on the principle of binomial distribution.Different age groups were compared with analysis of variance or chi-square test.Results The self-evaluation of PADAM symptom showed that the PADAM morbidity rate among ageing people was 39.87%(95%CI: 35.99%-43.75%),the difference among age groups had a statistical significance(P<0.05),and the scores for kinds of symptom all increased with age.The determined androgen level showed that the PADAM morbidity rate among ageing people in island area of Zhoushan was 30.72%(95%CI:27.06%-34.38%),and expect that the lutetropin level and Sex Hormone Binding Globulin(SHBG) increased with age,the total testosterone,free testosterone,and the index for free testosterone,etc.all decreased with age.Conclusion The PADAM morbidity rate among ageing people in island area of Zhoushan was relative high,and there existed difference among age groups.In the future,relevant study on PADAM should be furthered so as to provide scientific evidence for improving the physical and psychological health of ageing males,as well as their living quality.