Protein kinase CK2 and regulation of Ca2+-ATPase activity in brain neuron chromatin in rats during aging |
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| Authors: | Reikhardt B A Kulikova O G Sapronov N S |
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| Affiliation: | (1) Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg |
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| Abstract: | Protein kinase CK2 from neuronal chromatin phosphorylates myosin-like proteins isolated from rat brain chromatin. The protein kinase CK2 activator 1-ethyl-4,5-di(N-methylcarbamoyl)imidazole in vitro stimulated phosphorylation of myosin-like proteins and increased myosin-type Ca2+-ATPase activity in neuronal chromatin. After systemic administration this agent normalized Ca2+-ATPase activity of brain chromatin in aged rats. |
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| Keywords: | brain aging chromatin protein kinase CK2 myosin-like proteins |
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