| ER、PR、c-erbB-2在126例乳腺癌的表达及意义 |
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| 引用本文： | 周冠严,潘峰.ER、PR、c-erbB-2在126例乳腺癌的表达及意义[J].福建医药杂志,2004,26(1):24-25. |
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| 作者姓名： | 周冠严 潘峰 |
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| 作者单位： | 温州市肿瘤医院,325000 |
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| 摘 要： | 目的 探讨c-erbB-2和ER、PR在乳腺癌中的表达与转移及预后的关系。方法 应用免疫组化技术检测126例原发乳腺癌各抗体的表达情况。结果 ER的阳性率为45.2％,PR的阳性率为53.2％,c-erbB-2阳性率为68.3％。ER、PR其阳性表达率随着临床分期的增高和淋巴结转移数目的增多而逐渐降低,呈负相关,有显著性差异(P<0.05),c-erbB-2的阳性表达率随着临床分期的增高和淋巴结转移数目的增多而增高,呈正相关,有显著性差异(P<0.05)。ER、PR阳性表达率与c-erbB-2呈负相关。结论 ER、PR、c-erbB-2可作为判断乳腺癌生物学行为及预后的有效指标。
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| 关 键 词： | ER PR c-erbB-2 乳腺癌 肿瘤转移 预后 淋巴结转移 |
| 文章编号： | 1002-2600(2004)01-0024-02 |
The signification of the expression of ER, PR and c-erbB-2 in breast cancer of 126 cases |
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| Zhou Guanyan,Pan Feng. Wenzhou tumor hospital,wenzhou ,China.The signification of the expression of ER, PR and c-erbB-2 in breast cancer of 126 cases[J].Fujian Medical Journal,2004,26(1):24-25. |
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| Authors: | Zhou Guanyan Pan Feng Wenzhou tumor hospital wenzhou China |
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| Institution: | Zhou Guanyan,Pan Feng. Wenzhou tumor hospital,wenzhou 325000,China |
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| Abstract: | Objective To explore the relationship of metastases, prognosis and the expression of ER, PR and c--erB--2
in breast cancer. Method Using Immunohistochemical technique, detect the expression of ER, PR and c--erbB--2 in 126 cases
of breast cancer. Results ER positive rate is 45. 2%, PR positive rate 53. 2% and c--erbB--2 positive rate 68. 3%. EP, PR
expression rate is negatively correlated with cancer clinical stage and the number of lymphonode metastases (P<0. 05). C--erbB-
2 expression rate is reversed (P<0. 05). Conclusion ER, PR and c--erbB--2 maybe a valuable index as breast canacer prognosis
and biological behavior. |
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| Keywords: | Breast cancer LR PR c-erbB-2 Gene Immunohistochemistry |
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