不同降压药物对原发性高血压患者臂踝脉搏波动传导速度的影响

目的:评价不同降压药物对原发性高血压患者臂踝脉搏波动传导速度的影响。方法:将我院收治的原发性高血压患者120例随机分为3组,每组40例,分别给予培哚普利(ACEI组)、替米沙坦(ARB组)和氨氯地平(CCB组)治疗,在治疗后第1、3个月分别测定患者心率(HR)、收缩压(SBP)、舒张压(DBP)、脉压(PP)及臂踝脉搏波动传导速度(baPWV)。结果:治疗前3组患者SBP、DBP、PP、HR、baPWV无统计学差异(P>0.05);降压治疗后1个月3组患者SBP、DBP、PP、baPWV均较治疗前明显降低(P<0.01),治疗后3个月3组患者SBP、DBP、PP、baPWV均较治疗后1个月明显降低(P<0.01),3组患者治疗前后HR无显著变化(P>0.05)。治疗后3组baPWV变化(△baPWV)比较,ARB组>CCB组>ACEI组,3组数据间比较有统计学差异(P<0.05)。结论:培哚普利、氨氯地平、替米沙坦均可以改善高血压患者动脉弹性功能,其中替米沙坦改善动脉弹性功能最为明显。

Impact of Different Antihypertensive Drugs on Brachial-Ankle Pulse Wave Conduction Velocity of Essential Hypertension Patients

Objective: To evaluate the changes of brachial-ankle pulse wave conduction velocity after treatment with different antihypertensive drugs in essential hypertension patients.Methods: A total of 120 patients of essential hypertension were equally and randomly divided into three groups according to the antihypertensive drugs of telmisartan(ARB group),amlodipine(CCB group),and perindopril(ACEI group) respectively.Heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),and brachial-ankle pulse wave conduction velocity(baPWV) were measured after 1 month and 3 months respectively.Results: The SBP,DBP,PP,HR,and baPWV of the three groups had no significant difference before the treatment(P > 0.05).After treatment for one month and three months respectively,the SBP,DBP,PP,and baPWV were significantly decreased as compared with pretreatment(all P < 0.01).After treatment,the changes of baPWV(△baPWV) were different among the three groups,as ARB group CCB group ACEI group(P < 0.05).Conclusion: All the three kinds of drugs of perindopril,amlodipine,and telmisartan can improve arterial elasticity of hypertension patients, and telmisartan has the best effect.