对比增强超声造影对小肝癌诊断价值的Meta分析

目的:应用Meta分析探讨对比增强超声造影技术在诊断小肝癌中的临床应用价值。方法:以"超声造影、小肝癌"为检索词,检索2006年1月至2011年12月期间的Cochrance图书馆、Embase、中国学术期刊网全文数据库(CNKI)等数据库。利用循证医学方法,对采纳资料的原始数据进行异质性检验及质量评价,进而计算合并灵敏度和特异度,建立综合受试者工作特征曲线(SROC),计算曲线下面积评价对比增强超声造影技术诊断小肝癌的价值。根据循证医学中的证据质量评价标准,应用QUADAS项目对所采纳文献进行评价。结果:共入选9篇文献,670例病人。按照固定效应模型合并,超声造影诊断小肝癌的灵敏度和特异度分别为83%和86%,曲线下面积为93.41%。结论:超声造影对于小肝癌有很好的临床应用价值。

Diagnosis Value of Contrast-Enhanced Ultrasound Imaging Technology for Small Liver Cancer: Meta Analysis

Objective:To evaluate the value of contrast-enhanced ultrasound in diagnosing small hepatocellular carcinoma with Meta-analysis.Methods:With‘ultrasonic imaging’and‘small hepatocellular carcinoma’as the key words,evidence was collected from Cochrane Library,Embase,CNKI(2006.1-2011.12)and so on according to search strategy.Methods of evidence-based medicine were used to calculate the specificity,sensitivity,and summary receiver operating curve(SROC),and the area under the curve(AUC)were calculated to evaluate the diagnosis value of contrast enhancement ultrasonic imaging technology for small liver cancer.According to the quality evaluation standard of evidence-based medicine evidence,QUADAS items were used to evaluate the quality of evidence.Results:A total of 9studies were identified and the total number of case is 670.With the random effects pattern,the sensitivity and specificity of contrast-enhanced ultrasound in diagnosing small hepatocellular carcinoma were 83% and 86%,respectively.The AUC is 93.41%.Conclusion:The contrast-enhanced ultrasound will be helpful in diagnosing small hepatocellular.