穿孔素与艾滋病病毒感染

在HIV感染中,CTL是控制HIV感染细胞免疫应答中重要的效应细胞,主要通过穿孔素介导的颗粒胞吐途径,特异性清除HIV感染细胞,在HIV原发感染期对于快速消除病毒血症起关键作用,但是CTL仍不能彻底清除HIV。近年来有关穿孔素与HIV感染的相关性研究日益受到国内外学者的关注,此文将对穿孔素介导细胞毒效应的分子机制、穿孔素在HIV感染中作用的研究进展作一简要综述。

Perforin and HIV infection

In HIV infection, CTL is the key effective cell in the control of HIV infection, it deletes HIV-infected cells mainly through gyannule exocytosis pathway and plays a central role in eliminating viremia quickly in HIV primary infection, but CTL can't eradiate the virus completely. Recently, researchers at home and aboard are more and more interested in the correlation of perforin and HIV infection, so we briefly reviewed the advances in the molecular mechanisms of cytolytic effects mediated by perforin and the role of perforin in HIV infection.