| miRNA-122与肝细胞癌的研究进展 |
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| 引用本文： | 秦麒麟 综述 李清龙,审校.miRNA-122与肝细胞癌的研究进展[J].中国普通外科杂志,2015,24(1):105-109. |
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| 作者姓名： | 秦麒麟 综述 李清龙 审校 |
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| 作者单位： | 1. 中南大学湘雅医学院,湖南长沙,410013
2. 中南大学湘雅二医院普通外科,湖南长沙,410011 |
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| 摘 要： | microRNA（miRNA）是一类内源性非编码RNA，它参与癌症发生发展过程中多个通路的调控。肝细胞癌（HCC）是最常见的恶性肿瘤之一，目前缺乏有效的治疗手段，预后较差。研究表明，miR-122在HCC的发生发展中起着重要的抑制作用，它可能成为新的HCC诊断和预后的重要生物标记以及治疗靶点。笔者就miR-122与HCC的关系研究进展进行综述。
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| 关 键 词： | 癌 肝细胞 微RNAs 综述文献 |
| 收稿时间： | 2014/10/13 0:00:00 |
| 修稿时间： | 2014/12/19 0:00:00 |
Research progress of miRNA-122 and hepatocellular carcinoma |
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| QIN Qilin,LI Qinglong.Research progress of miRNA-122 and hepatocellular carcinoma[J].Chinese Journal of General Surgery,2015,24(1):105-109. |
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| Authors: | QIN Qilin LI Qinglong |
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| Institution: | (1. Xiangya School of Medicine, Central South University, Changsha 410013, China; 2. Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China) |
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| Abstract: | MicroRNAs (miRNAs) are endogenous non-coding RNAs, participating in diverse pathways that regulate tumor occurrence and progression. Hepatocellular carcinoma (HCC) is one of the most common malignancies, with poor prognosis due to lack of effective treatment modalities at present. Studies have showed that miR-122 plays an important suppressive role in genesis and progression of HCC, so it may probably become a novel biomarker for diagnosis and prognosis as well as therapeutic target of HCC. Here, the authors present the research progress in relationship between miR-122 and HCC. |
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| Keywords: | Carcinoma Hepatocellular MicroRNAs Review |
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