心肌钙泵新的调节蛋白——sarcolipin 研究进展

Sarcolipin (SLN) 是新近发现存在于肌浆网中的小分子膜蛋白,分子质量为3 kD,由31 个氨基酸构成,与受磷蛋白(phospholamban, PLB) 属于同一蛋白家族。SLN 可抑制肌浆网钙泵( sarcoplasmic reticulum Ca²⁺ ATPase,SERCA ) 活性,降低其与Ca²⁺ 的亲和力,通过独立或与PLB 协同作用影响SERCA 活性,导致细胞内钙稳态失衡,降低心肌收缩力,从而发展为心衰。

Research progress of sarcolipin-a new regulatory protein of sarcoplasmic reticulum Ca2+ ATPase

Sarcolipin (SLN) is a 3 kD membrane protein found in sarcoplasmic reticulum (SR). It has 31 amino acid residues; SLN and phopholamban (PLB) are belong to the same protein family, so they have similar physiological functions. SLN inhibits sarcoplasmic reticulum Ca(2+) ATPase (SERCA) activity and reduces its affinity of Ca(2+), resulting in dysfunction of myocardial contraction and heart failure. However, much remains to be elucidated. SLN independently or in conjunction with PLB affects SERCA activity, imbalancing intracellular calcium homeostasis, and reducing myocardial contractivity; these effects promote the development of heart failure.