| 肝硬化患者肿瘤坏死因子与胰岛素抵抗的相关性 |
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| 引用本文： | 刘进,田怡,刘建生,付极,马铭,张晓红. 肝硬化患者肿瘤坏死因子与胰岛素抵抗的相关性[J]. 临床消化病杂志, 2006, 18(5): 277-278 |
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| 作者姓名： | 刘进 田怡 刘建生 付极 马铭 张晓红 |
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| 作者单位： | 上海市瑞金医院集团闵行医院消化科,上海,201100;上海市瑞金医院集团闵行医院消化科,上海,201100;上海市瑞金医院集团闵行医院消化科,上海,201100;上海市瑞金医院集团闵行医院消化科,上海,201100;上海市瑞金医院集团闵行医院消化科,上海,201100;上海市瑞金医院集团闵行医院消化科,上海,201100 |
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| 基金项目： | 上海市科学技术委员会资助（编号054119625）. |
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| 摘 要： | 目的探讨肝硬化患者肿瘤坏死因子水平与胰岛素抵抗的关系。方法测定73例肝硬化患者及30例健康人血清肿瘤坏死因子水平及相关临床生化参数,并计算胰岛素敏感指数和体重指数。结果肝硬化组肿瘤坏死因子水平明显高于正常对照组,肿瘤坏死因子与胰岛素水平呈负相关,而与胰岛素敏感指数呈正相关。结论肝硬化患者血清肿瘤坏死因子水平明显升高,其可能作为肝功能的评价指标;肿瘤坏死因子水平与肝硬化患者胰岛素抵抗密切相关。
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| 关 键 词： | 肝硬化 肿瘤坏死因子 胰岛素抵抗 |
| 文章编号： | 1005-541X（2006）05-277-02 |
| 收稿时间： | 2006-04-06 |
| 修稿时间： | 2006-04-06 |
Study of the Relationship Between Tumor Necrosis Factor and Insulin Resistance in Liver Cirrhosis |
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| LIU Jin,TIAN Yi,LIU Jian-sheng,FU Ji,MA Ming,ZHANG Xiao-hong. Study of the Relationship Between Tumor Necrosis Factor and Insulin Resistance in Liver Cirrhosis[J]. Chinese Journal of Clinical Gastroenterology, 2006, 18(5): 277-278 |
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| Authors: | LIU Jin TIAN Yi LIU Jian-sheng FU Ji MA Ming ZHANG Xiao-hong |
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| Affiliation: | Department of Gastroenterlogy, the RuiJin Hospital Bloc Minhang Hospital, Shanghai 201100, China |
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| Abstract: | Objective To study the relationship between tumor necrosis factor and insulin resistance in patients with liver cirrhosis.Methods Tumor necrosis factor levels was determined in 73 patients with cirrhosis and 30 healthy controls and were correlated with various clinical and biochemical parameters.Insulin sensitivity index and BMI were counted.Results Tumor necrosis factor levels was significantly elevated in patients with cirrhosis comparing with the control.Tumor necrosis factor levels in cirrhosis correlated positively with insulin sensitivity index and negatively with insulin levels.Conclusion Serum tumor necrosis factor levels in cirrhosis is significantly elevated.It can be an index of evaluating liver function for cirrhosis.Tumor necrosis factor levels correlated with insulin resistance of cirrhosis. |
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| Keywords: | Cirrhosis Tumor necrosis factor Insulin resistance |
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