Creutzfeldt-Jakob disease with tubulovesicular structures: an ultrastructural study. |
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Authors: | W Split J Janusik J Alwasiak W Papierz M Barcikowska P P Liberski |
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Affiliation: | Department of Neurology, Regional Hospital, Zgierz, Poland. |
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Abstract: | Tubulovesicular structures (TVS) have been consistently observed in brain tissue of the transmissible spongiform virus encephalopathies such as natural and experimental scrapie, bovine spongiform encephalopathy and experimentally induced Creutzfeldt-Jakob disease (CJD). TVS were recently demonstrated in 3 cases of naturally occurring CJD. We report here the presence of TVS in another human brain with CJD, as detected in all 3 specimens by thin section electron microscopy. Their occurrence in all types of spongiform encephalopathies, irrespective of the affected host and the strain of infectious agent, emphasizes their biological significance. |
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