Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein |
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Authors: | Fusheng Yang, Kenji U da, Ping-Ping Chen, Karen Hsiao Ashe,Greg M. Cole |
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Affiliation: | Fusheng Yang, Kenji Uéda, Ping-Ping Chen, Karen Hsiao Ashe,Greg M. Cole, |
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Abstract: | Patients with the Lewy body variant (LBV) of Alzheimer's disease (AD) have ubiquitinated intraneuronal and neuritic accumulations of α-synuclein and show less neuron loss and tau pathology than other AD patients. Aged Tg2576 transgenic mice overexpressing human βAPP695. KM670/671NL have limited neuron loss and tau pathology, but frequent ubiquitin- and α-synuclein-positive, tau-negative neurites resembling those seen in the LBV of AD. |
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Keywords: | α -Synuclein Amyloid precursor Transgenic Alzheimer's Parkinson's Lewy |
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