心肌肌钙蛋白Ⅰ的临床应用研究

探讨心肌肌钙蛋白１在缺血性心脏病中的诊断与鉴别方面的临床应用价值。结果表明：心肌肌钙蛋白１对急性心肌梗死的诊断灵敏度高于肌酸激酶、肌酸激酶曲酶ＭＢ，乳酸脱氢酶、谷草转氨酶及α－羟丁酸脱氢酶；其特异性在稳定型心绞痛组与肌酸激酶与肌酸激酶同工酶ＭＢ相当，而较α－羟丁酸脱氢酶、乳酸脱氢酶和谷草转氨酶炕，此外，主肌肌钙蛋白Ｉ对不稳定型心绞痛也有一定的诊断价值。提示心肌甩钙蛋白Ｉ是一种心肌损伤的特异性标志物

Clinical evaluation of cardiac troponin I in ischemic heart diseases]

The detection of cardiac troponin I(cTnI), including serum or plasma, was evaluated in 114 patients with ischemic heart diseases or other heart diseases. The results were that the sensitivity of cTnI detection(qualitative analysis, cutoff is 0.2 ng.ml-1) was higher than that of creatine kinase(CK), creatine kinase-MB(CK-MB), alpha-hydroxybutyrate dehydrogenase(alpha-HBD), lactic dehydrogenase(LDH), and aspartic transaminase(AST) for diagnosing acute myocardial infarction (AMI) (93.2% vs 68.2%, 68.2%, 65.9%, 65.9%, and 75.0%; P < 0.05; respectively). The specificity of cTnI detection was higher than that of alpha-HBD, LDH, and AST(95.2% vs 81.0%, 73.8%, and 54.0%; P < 0.05; respectively) and similar to CK and CK-MB(95.2% vs 83.3% and 83.3%; P > 0.05; respectively). On the other hand, the sensitivity of cTnI in patients with unstable angina pectoris was 45.5%. It was higher than stable angina pectoris and lower than AMI. The results suggest that the cardiac troponin I is a better cardiac injury marker than other cardiac markers for diagnosing AMI.