异丙酚,依托咪酯地中低温体外循环期间脑氧代谢的影响

在２０例瓣膜置换术病人中，观察异丙酚（Ｐ组）和依托咪酯（Ｅ组）对中低温体外循环期间脑氧代谢的影响，结果：两组病人均随鼻咽温降低，ＳｊＯ２、ＣｊＯ２升高、ＣＥＯ２下降；复温后ＳｊＯ２下降，ＣＥＯ２明显升高。复温至３５℃时，Ｐ组ＳｊＯ２和ＣｊＯ２高于Ｅ组，ＣｊＯ２低于Ｅ组。提示：异丙酚降低复温期脑代谢、减少脑氧耗、脑氧摄取率的作用优于依托咪酯。。

Effects of propofol and etomidate on cerebral oxygen supply and demand balance during middle hypothermia cardiopulmonary bypass]

Effects of propofol(Group P) and etomidate(Group E) on cerebral oxygen supply and demand balance during middle hypothermia cardiopulmonary bypass(CPB) were studied in twenty patients undergoing cardiac valve replacement. Arterial blood and jugular bulb blood were taken to analyse blood gas, and cerebral oxygen content were caculated. RESULT: During hypothermia, jugular bulb oxygen saturation(SjO2), jugular bulb blood oxygen content(CjO2) increased; cerebral oxygen extraction rate(CEO2) decreased significantly in two groups(P < 0.05). During rewarming SjO2, CjO2 were significantly decreased, CEO2 increased compared with that before rewarming and hypothermia in two gbroups (P < 0.05). In Group P, SjO2 and CjO2 were higher, CEO2 lower than those in Group E respectively during rewarming (P < 0.05). CONCULUSION: The activity of propofol reduced cerebral metabolism, cerebral oxygen consumption and CEO2 is better than that of etomidate.