| 孔源性视网膜脱离视网膜下液中IL—1β和TNF—α与PVR的关系 |
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| 引用本文： | 陈百华,姜德咏.孔源性视网膜脱离视网膜下液中IL—1β和TNF—α与PVR的关系[J].湖南医科大学学报,1998,23(5):483-485. |
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| 作者姓名： | 陈百华 姜德咏 |
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| 作者单位： | [1]湖南医科大学第三附属医院眼科 [2]附二院眼科 |
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| 摘 要： | 用酶联免疫吸附实验（ＥＬＩＳＡ）法测定４９例单眼视网膜脱离患者视网膜下液中ＩＬ－１β及ＴＮＦ－α含量。结果表明：所有视网膜下液中ＩＬ－１β含量增加且与ＰＶＲ病变严重程度呈线性正相关；与年龄，性别，视网膜脱离范围，裂孔数目无明显相关。４９例视网膜下液中仅１８例含ＴＮＦ－α，其中ＰＶＲ－Ｃ１级以上病例占１６例（３２．６５％），提示ＩＬ－１β和ＴＮＦ－α参与ＰＶＲ的形成和发展过程。
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| 关 键 词： | 视网膜脱离 IL－1β TNF－α 视网膜病变 |
Relationship between IL-1 beta and TNF-alpha in subretinal fluids of rhegmatogenous retinal detachment with PVR] |
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| B Chen,D Jiand,P Huang,L Tang.Relationship between IL-1 beta and TNF-alpha in subretinal fluids of rhegmatogenous retinal detachment with PVR][J].Bulletin of Hunan Medical University,1998,23(5):483-485. |
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| Authors: | B Chen D Jiand P Huang L Tang |
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| Institution: | Department of Ophthalmology, Third Affiliated Hospital, Hunan Medical University, Changsha. |
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| Abstract: | The concentrations of IL-1 beta and TNF-alpha in subretinal fluids from 49 patients with rhegmatogenous retinal detachment with proliferative vitreoretinopathy(PVR) were measured by Enzyme-linked immunosorbent assay (ELISA). The results showed that all subretinal fluids contained IL-1 beta, their concentrations were positive correlation with severity of PVR (r = 0.677) and no correlation with age, sex, holes, ranges and times of retinal detachment, TNF-alpha was detected in 18/49 subretinal fluids including 2 patients with PVR-1 beta and 16 patients with PVR-C and the above cases. It suggested that IL-1 beta and TNF-a are involved in the pathogenesis of PVR. |
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