Once initiated,viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6 |
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Authors: | Jane E Libbey Nikki J Kennett Karen S Wilcox H Steve White Robert S Fujinami |
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Institution: | Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. |
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Abstract: | Theiler’s murine encephalomyelitis virus infection of C57BL/6 mice results in acute behavioral seizures in 50% of the mice.
Treatment of infected mice with minocycline or infection of interleukin (IL)-6-deficient chimeric mice results in a significant
decrease in the number of mice developing seizures. However, in those mice that do develop seizures, the pathological changes
(neuronal cell loss, inflammation perivascular cuffing, gliosis, activated microglia/macrophages]), and the numbers of virus
infected cells in minocycline-treated or IL-6-deficient chimeric mice are very similar. Therefore, once seizures develop,
the pathological changes are consistent regardless of the treatment or genetic background. |
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