抗心磷脂抗体及抗核抗体与反复自然流产的关系

目的：探讨抗心磷脂抗体（ACA）及抗核抗体（ANA）与反复自然流产（RSA）的关系。 方法：采用ELISA法检测98例RSA患者及40例正常妇女血清ACA和ANA。 结果：RSA组ACA阳性率为32.7%，明显高于对照组（5.0%，P<0.01）；早期与晚期RSA两组间比较，ACA阳性率差异无显著性（P>0.05），RSA 2次与RSA≥3次两组间比较，ACA阳性率差异无显著性（P>0.05）；ACA IgM、IgG、IgA中以IgG、IgM检出率较高，ACA IgM、IgG、IgA同时阳性者仅4例；阳性和强阳性ACA占37.5%(11/32)，其余均为ACA弱阳性；RSA患者ANA阳性率为17.3%，较对照组（2.5%）明显增高（P<0.05）。 结论：ACA及ANA与RSA有关，可作为RSA免疫因素的辅助诊断指标。

Relations of recurrent spontaneous abortion with anticardiolipin antibody and antinuclear antibody

Objective To explore the relations of recurrent spontaneous abortion (RSA) with anticardiolipin antibody (ACA) and antinuclear antibody (ANA). Methods The levels of ACA and ANA in serum of 98 RSA patients and 40 normal women were detected by ELISA. Results The positive rate of ACA in RSA patients (32.7%) was obviously higher than normal wowen (5.0%) (P<0.01);there was no difference of the positive rate of ACA in statistics between early and late RSA, as well as between 2 times and more than 2 times abortions of RSA patients(P>0.05); the positive rates of IgG and IgM were higher among IgM,IgG and IgA of ACA, only 4 RSA patients were positive in all, the positive rate of middle and high level of ACA was 37.5%(11/32), the rest were low levels. The positive rate of ANA in RSA patients (17.3%) was obviously higher than that in normal women (2.5%) (P<0.05). Conclusion ACA and ANA are related with RSA, and may be regarded as a immunological assistant diagnostic index.