肿瘤浸润性树突状细胞与粘蛋白MUC1在前列腺癌与前列腺增生中的表达研究

目的 :探讨上皮特异性肿瘤蛋白 (MUC1)与肿瘤浸润性树突状细胞 (TIDC)在前列腺癌及前列腺增生组织中的表达。　方法 :采用免疫组织化学SP法检测MUC1和TIDC在 30例前列腺癌、2 0例前列腺增生组织的表达。结果 :MUC1在前列腺癌、前列腺增生组织中均表达 ,MUC1的染色分型同肿瘤的病理分级密切相关 (P <0 .0 0 1)。TIDC的数量在高分化与低分化前列腺癌间差异有显著性 (P <0 .0 0 1)。　结论 :MUC1的表达模式和TIDC数量的监测可以作为前列腺癌恶性程度和预后的判断指标。TIDC的减少可能是肿瘤免疫逃逸和耐受的重要环节 ,肿瘤细胞表面高密度的MUC1可能参与前列腺癌侵袭转移和激素耐受机制。

Tumor Infiltrating Dendritic Cells and Mucin1 Gene Expression in Benign Prostatic Hyperplasia and Prostate Cancer

Objective: To study the expression of Mucin 1 gene and tumor infiltrating dendritic cells(TIDC) in the tissues of benign prostatic hyperplasia (BPH) and prostate cancer. Methods: Mucin1 and TIDC were detected in 20 specimens of BPH and 30 specimens of prostate cancer by immunohistochemistry SP method. Results: MUC1 expressed in both prostate cancer and BPH. The staining patterns were significantly associated with tumor pathological grade ( P < 0.001 ). The number of TIDC was negatively correlated with tumor pathological grade, the higher the grade, the smaller the number of TIDC ( P < 0.001 ). Conclusions: The expression pattern of MUC1 and the number of TIDC could be considered as useful markers to evaluate the malignant degree and prognosis of prostate cancer. The decrease of TIDC plays an important role in tumor immune evasion and immune tolerance. Highly expressed MUC1 could lead to the failure of hormonal treatment for prostate cancer,and contribute much to tumor infiltration and metastasis.