Early use of statins in acute coronary syndromes |
| |
Authors: | Joshua M Spin Randall H Vagelos |
| |
Institution: | (1) Falk CVRB - 279, Stanford University Medical Center, 94305-5246 Stanford, CA, USA |
| |
Abstract: | This review examines the use of statin medications early in the clinical course of acute coronary syndrome (ACS). Available
data demonstrate that there are clear clinical benefits to this practice. Numerous previous studies have documented the primary
and secondary benefits of statins in the prevention of coronary events. Recent trials show that when statins are used during
hospital admissions for ACS, patients experience decreased recurrent myocardial infarction, lower death rates, and fewer repeat
hospitalizations for ischemia or revascularization. Several studies suggest that the positive effects of statins on plaque
stabilization, inflammation, thrombosis, and endothelial function may be independent of lipid levels. There is also an emerging
view that beneficial lipid-lowering with statins in high-risk patients has no lower limit. This information suggests that
all patients admitted for ACS should be treated with statins, regardless of cholesterol levels. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|