| 新辅助化疗对乳腺癌ER、PR、C-erbB-2、P53、Ki-67表达的影响 |
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| 引用本文： | 廖富毅,杨劼,潘瑞琳.新辅助化疗对乳腺癌ER、PR、C-erbB-2、P53、Ki-67表达的影响[J].岭南现代临床外科,2007,7(2):111-113. |
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| 作者姓名： | 廖富毅 杨劼 潘瑞琳 |
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| 作者单位： | 广东省佛山市第一人民医院胸外乳腺外科,528000 |
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| 摘 要： | 目的 探讨新辅助化疗对乳腺癌ER、PR、C-erbB-2、P53、Ki-67表达的影响。方法 通过免疫组化检测化疗前后38例乳腺癌ER、PR、C-erbB-2、P53、Ki-67的表达。结果 新辅助化疗前后ER、PR状态各有9例发生变化,C-erbB-2状态各有8例发生变化,P53状态各有10例发生变化,比较差异均无统计学意义;Ki-67状态有17例发生改变,比较差异有统计学意义。结论 新辅助化疗对ER、PR、C-erbB-2、P53表达状态无显著影响,而能显著降低Ki-67的表达。
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| 关 键 词： | 乳腺肿瘤 新辅助化疗 雌激素受体 孕激素受体 C-erbB-2 |
| 文章编号： | 1009-976X（2007）02-0111-03 |
| 修稿时间： | 2007-03-06 |
Effects of neoadjuvant chemotherapy on expression of ER、PR、C-erbB-2、P53 and Ki-67 in breast cancer |
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| LIAO Fuyi,YANG Jie,PAN Ruilin.Effects of neoadjuvant chemotherapy on expression of ER、PR、C-erbB-2、P53 and Ki-67 in breast cancer[J].Lingnan Modern Clinics in Surgery,2007,7(2):111-113. |
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| Authors: | LIAO Fuyi YANG Jie PAN Ruilin |
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| Abstract: | Objective To study the effect of neoadjuvant chemotherapy on expressions of ER, PR.C-erbB-2,P53 and Ki-67 in breast cancer. Methods Expressions of ER,PR,C-erbB-2,P53,Ki- 67 of 38 patients with breast cancer were measured by immunohistochemistry before and after neoadjuvant chemotherapy. Results Among all the 38 cases, the status of ER, PR, C-erbB-2 and P53 had change only in 9,9,8 and 10 cases respectively. There was no statistical difference significantly before and after neoadjuvant chemotherapy. The status of ki-67 had change in 17 cases. And the difference had statistical significance before and after neoadjuvant chemotherapy. Conclusion Neoadjuvant chemo- therapy has no signifieant influence on status of ER, PR, C-erbB-2 and P53, but it can reduce the cxpression of ki-67 significantly. |
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| Keywords: | Bresat neoplasm Neoadjuvant chemotherapy Estrogen receptor Progestogen receptor C-erbB-2 |
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