Effect of amphetamine on sucrose-reinforced lever pressing: interaction with food deprivation |
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| Authors: | H H Samson |
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| Affiliation: | 1. Health Services Research and Development, Department of Veterans Affairs Puget Sound Health Care System;2. Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA;1. Kansas State University, Manhattan, KS 66506, United States;2. North Central College, Department of Psychology, 30 North Brainard St, Naperville, IL 60540, United States;1. Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States;2. Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States;3. School of Nursing, Louisiana State University Health Sciences Center, New Orleans, LA 70112, United States |
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| Abstract: | Rats were trained to lever press on a Fixed Ratio Schedule 8 using sucrose reinforcement in one of two feeding conditions: ad lib food and water available in the home cage; reduced feeding in order to maintain the animals at 80% of their free feeding body weight. The effect of three doses of d-amphetamine (0.10, 0.25 and 0.50 mg/kg) on lever pressing was examined for each feeding condition. A systematic decrease in responding as dose increased was found in the ad lib feeding condition while only the highest dose had any effect on responding in the food restricted animals. Thus, it appeared that the effect of food deprivation was to shift the amphetamine dose-response curve to the right. |
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