补锌联合金叶败毒颗粒治疗人巨细胞病毒感染的临床观察

目的探讨补锌联合中药治疗人巨细胞病毒(HCMV)感染的疗效。方法将HCMV—IgM阳性患者140例随机分为4组，即对照组(单纯服用金叶败毒颗粒)及大、中、小剂量治疗组(口服金叶败毒颗粒及30、20、10mg／d的葡萄糖酸锌片)，每组均为35例，观察HCMV—IgM的转阴率。结果对照组与小剂量治疗组比较，差异无显著性(P>0．05)；中、大剂量治疗组组间比较，差异无显著性(P>0．05)；对照组与中、大剂量治疗组比较，HCMV—IgM转阴率明显降低(X^2=9．285，P=0．002)：结论补锌联合中药治疗可明显提高HCMV—IgM阳性的转阴率，给予20mg／d葡萄糖酸锌片联合中药治疗是最佳剂量选择。

Observation on Clinical Efficacy of Combined Therapy of Zinc Supplement and Jinye Baidu Granule in Treating Human Cytomegalovirus Infection

ObjectiveTo explore the clinical efficacy of the combined therapy of zinc supplement and Jinye Baidu granule (JBG) on human cytomegalovirus (HCMV) infection. MethodsOne hundred and forty patients with positive HCMV-IgM were randomly divided into four groups, with 35 cases in each group, that is, the control group (only medicated with JBG), the high-, moderate- and low-dose zinc combined groups (treated with JBG combined with zinc gluconate tablet at dose of 30mg, 20mg, 10mg every day respectively). The negative conversion rate of HCMV-IgM was observed. ResultsInsignificant difference in the negative conversion rate was shown in comparison of the control group with the low dose group (P>0.05), and in comparison of the high dose with the moderate dose group (P>0.05); however, the rate was significantly lower in the control group than that in the moderate dose and high dose group (P<0.05). ConclusionCombined therapy of zinc supplement and JBG can significantly increase the negative conversion rate of HCMV-IgM. The optimal dosage of zinc gluconate tablet was 20 mg once a day.