| 口腔速崩片的研制 |
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| 引用本文： | 陈岚,武新安,张国荣,李鉴桥.口腔速崩片的研制[J].中国药房,2001,12(11):657-658. |
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| 作者姓名： | 陈岚 武新安 张国荣 李鉴桥 |
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| 作者单位： | 兰州医学院附属第一医院,兰州市,730000 |
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| 基金项目： | 甘肃省科委资助项目(QS-002-C33-016) |
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| 摘 要： | 目的 :研制、开发口腔速崩片。方法 :以崩解时限和溶出度为指标筛选确定处方和工艺。结果 :制得的口腔速崩片能在20s内完全崩解 ,5min的药物累积溶出度达到99 %。结论 :采用国内现有设备 ,运用适宜的赋形剂及工艺可制出口腔速崩片
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| 关 键 词： | 口腔速崩片 赋形剂 崩解时限 溶出度 |
| 文章编号： | 1001-0408(2001)11-0657-02 |
| 修稿时间： | 2001年4月26日 |
Preparation of Rapid-disintegrated Lozenge |
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| CHEN Lan,WU Xinan,ZHANG Guorong,LI Jianqiao.Preparation of Rapid-disintegrated Lozenge[J].China Pharmacy,2001,12(11):657-658. |
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| Authors: | CHEN Lan WU Xinan ZHANG Guorong LI Jianqiao |
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| Abstract: | OBJECTIVE:To prepare a rapid-disintegrated lozenge METHODS:The formula and technology were decided by taking the disintegrating time and dissolubility as standard RESULTS:The lozenge could completely disintegrate in 20s and the accumnlated dissolubility of the model drug was 99% after 5 minutes in phosphate buffer(pH=6 80) CONCLUSION:Using now available equipment,suitable excipients and workmanship can prepare a rapid-disintegrated lozenge |
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| Keywords: | rapid-disintegrated lozenge excipient disintegrating time dissolubility |
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