| 实验性肺水肿大鼠血浆中内皮素、一氧化氮含量的变化以及硝普钠、川芎嗪对其的影响 |
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| 引用本文： | 桂怡,戴顺龄,段金虹,李春涛,斯琴,程锦轩.实验性肺水肿大鼠血浆中内皮素、一氧化氮含量的变化以及硝普钠、川芎嗪对其的影响[J].微循环学杂志,1998(3). |
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| 作者姓名： | 桂怡 戴顺龄 段金虹 李春涛 斯琴 程锦轩 |
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| 作者单位： | 1. 北京北方医院,北京100081
2. 中国协和医科大学、中国医学科学院基础医学研究所 |
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| 摘 要： | 在肾上腺素所致大鼠肺水肿实验中，发现其血浆中内皮素（ET－1）明显升高，一氧化氮（NO）稍有增高，但ET－1的增幅远远大于NO的增幅，动物均在15min内死亡。ET的增高与儿茶酚胺的升高有密切关系。经硝普纳（NP）、川芎嗪（TMP）预防后，ET－1与NO基本恢复正常，趋于平衡，动物长期存活。提示：肺水肿时NO相对于ET－1明显降低，NP、TMP可对NO与ET的平衡起调节作用。
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| 关 键 词： | 肺水肿 内皮素 一氧化氮 硝普钠 川芎嗪 大鼠 |
Effects of Nitroprusside and Tetramethylpyrazine on Endothelin and Nitric Oxide Level of Plasma in Pulmonary Edema Rats |
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| Gui Yi,DaiShunling,Duan Jinhong,et al.Effects of Nitroprusside and Tetramethylpyrazine on Endothelin and Nitric Oxide Level of Plasma in Pulmonary Edema Rats[J].Chinese Journal of Microcirculation,1998(3). |
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| Authors: | Gui Yi DaiShunling Duan Jinhong |
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| Abstract: | Pulmonary edema(PE) induced by edrenalin (AD) administration in rats issimilar to neucrogenic PE. In PE, endothelin(ET-1 ) increases markedly, nitricoxide (NO) increases slightly. The animal died within 15 min after AD injection. In Nitroprusside(NP) or Tetramethylpyrazine (TMP) preventive rats themortality were decreased markedly and survive longer. Results suggest: In PE,the decrease of NO content is relative. It was concluded that NP and TMP canled ET-1, NO in plasma return to normal level. |
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| Keywords: | Pulmonary edema Endothelin Nitric oxide Nitroprusside Tetramethylpyrazine Rat |
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