| 缺氧诱导分化因子-1对小鼠主动脉平滑肌细胞增生作用的研究 |
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| 引用本文： | 高凌云,李福平,何作云,牟娇. 缺氧诱导分化因子-1对小鼠主动脉平滑肌细胞增生作用的研究[J]. 重庆医学, 2008, 37(12): 1312-1313 |
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| 作者姓名： | 高凌云 李福平 何作云 牟娇 |
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| 作者单位： | 第三军医大学新桥医院心血管内科,重庆,400037;第三军医大学新桥医院心血管内科,重庆,400037;第三军医大学新桥医院心血管内科,重庆,400037;第三军医大学新桥医院心血管内科,重庆,400037 |
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| 摘 要： | 目的探讨缺氧诱导分化因子-1对血管平滑肌细胞的致增生效应。方法采用改良贴块法培养小鼠主动脉平滑肌细胞,通过测定细胞甲基-3H胸腺嘧啶核苷(3H-TdR)掺入、MTT廓清和增殖细胞核抗原(PCNA)表达来评价不同浓度缺氧诱导分化因子-1对血管平滑肌细胞增生的影响。结果缺氧诱导分化因子-1呈剂量依赖性地增加平滑肌细胞的3H-TdR掺入、MTT廓清和PCNA的表达。结论缺氧诱导分化因子-1可促进血管平滑肌细胞增生。
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| 关 键 词： | 缺氧诱导分化因子-1 血管平滑肌细胞 增殖 |
Effects of FIZZ1 on proliferation of mouse aortic smooth muscle cells |
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| GAO Ling-yun,LI Fu-ping,HE Zuo-yun,et al.. Effects of FIZZ1 on proliferation of mouse aortic smooth muscle cells[J]. Chongqing Medical Journal, 2008, 37(12): 1312-1313 |
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| Authors: | GAO Ling-yun LI Fu-ping HE Zuo-yun et al. |
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| Abstract: | Objective To study the proliferative effects of FIZZ1(found in inflammatory zone 1) on cultured mouse vascular smooth muscle cells(VSMCs).Methods Methyl-3H thymidine(3H-TdR) incorporation,MTT cleaning and the expression of PCNA were determined on VSMCs after stimulation by FIZZ1.Results FIZZ1 caused marked increase of 3H-TdR incorporation,MTT cleaning and the expression of PCNA in VSMCs dose-dependently.Conclusion FIZZ1 dose-dependently stimulated the proliferation of VSMCs. |
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| Keywords: | FIZZ1 VSMCs proliferation |
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