中国汉族人群中染色体9p21.3基因多态性与阿尔茨海默病的相关性研究

目的：探讨中国汉族人群中染色体9p21.3 rs1333049基因与阿尔茨海默病（AD）的相关性。方法：采用基质辅助激光解吸电离飞行时间质谱技术检测266例AD患者（AD组）与323例非AD者（对照组）的rs1333049基因多态性分布,并通过x~2检验和Logistic回归进行疾病关联分析。结果：AD组和对照组SNP rs1333049基因型频率及等位基因频率差异均有统计学意义（P〈0.05）;调整混杂因素影响后Logistic回归分析表明,在显性模型和递加模型中,两组的分布差异仍有统计学意义（P〈0.05）,提示等位基因C增加了AD发病的易感性。结论：中国汉族人群中rs1333049基因与AD的发病存在相关性。

Association between Chromosome 9p21.3 Polymorphism and Alzheimer's Disease in Chinese Han Population

Aim：To explore the association between rsl333049 single nucleotide polymorphism（SNP） at chromosome 9p21.3 and AD in Chinese Han population.Methods：The polymorphism of rsl333049 of 266 AD patients and 323 controls was detected by using matrix-assisted laser desorption/ionization time of flight mass spectrometry（MALDI-TOFMS）,and the relation between rsl333049 polymorphism and AD was analyzed by Chi-square test and Logistic regression.Results：There were differences in the frequency of genotypes and alleles between the patients and controls（P0.05）.After confounding variables were adjusted,Logistic regression analysis demonstrated there were statistical distribution significance in dominant model and additive model（P0.05） in two groups,indicating that C allele increased the susceptibility of AD.Conclusion： The association was found between SNF rs1333049 and AD in Chinese Han population.