Skin occlusion and irritant and allergic contact dermatitis: an overview |
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| Authors: | Zhai H Maibach H I |
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| Institution: | Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, San Francisco, CA 94143-0989, USA. |
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| Abstract: | Occlusion, widely used to enhance percutaneous absorption of drugs, also increases penetration of other chemicals and antigens, and hence may exacerbate irritant and allergic contact dermatitis. This overview summarizes the adverse effects of occlusion. |
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| Keywords: | enhancer irritant contact dermatitis occlusion percutaneous absorption-penetration stratum corneum transdermal therapeutic systems transepidermal water loss |
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